‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues
نویسندگان
چکیده
منابع مشابه
Glucose-responsive insulin delivery systems.
La diabetes es un trastorno de muy alta prevalencia, caracterizado por un déficit de acción insulínica, que da lugar a concentraciones elevadas de glucosa en sangre. Las terapias sustitutivas son muy imperfectas: en pocos casos consiguen controlar de manera estable los valores de glucemia, se adaptan mal a las perturbaciones (ingestas, ejercicio, etc.), provocan hipoglucemias e implican un esfu...
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Although previous studies have attempted to create "electronics-free" insulin delivery systems using glucose oxidase and sugar-binding lectins as a glucose-sensing mechanism, no successful clinical translation has hitherto been made. These protein-based materials are intolerant of long-term use and storage because of their denaturing and/or cytotoxic properties. We provide a solution by designi...
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Boronic acids, known to bind diols, were screened to identify non-inflammatory cross-linkers for the preparation of glucose sensitive and insulin releasing agglomerates of liposomes (Agglomerated Vesicle Technology-AVT). This was done in order to select a suitable replacement for the previously used cross-linker, ConcanavalinA (ConA), a lectin known to have both toxic and inflammatory effects i...
متن کاملInsulin analogues.
N Engl J Med 2005;352:174-83. Copyright © 2005 Massachusetts Medical Society. he discovery of insulin more than 80 years ago is considered one of the greatest medical breakthroughs of the 20th century. 1 The first commercial insulin preparations contained numerous impurities and varied in potency from lot to lot by as much as 25 percent. Manufacturing techniques improved rapidly, however, which...
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OBJECTIVE Attempts to build an artificial pancreas by using subcutaneous insulin delivery from a portable pump guided by an subcutaneous glucose sensor have encountered delays and variability of insulin absorption. We tested closed-loop intraperitoneal insulin infusion from an implanted pump driven by an subcutaneous glucose sensor via a proportional-integral-derivative (PID) algorithm. RESEA...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2021
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-021-05422-6